Anti-inflammatory activity of Lactobacillus spp. and Rhodopseudomonas palustris probiotics

Background: Probiotics have been used for many years to promote human health by mitigating inflammation. However, its mechanics not fully elucidated. During inflammation, excessive and/or prolonged production of pro-inflammatory cytokines is related with various inflammatory diseases and cancer. Several probiotics reported as playing a role in suppressing the level pro-inflammatory cytokines, body attempts recover. The aim this study was evaluate anti-inflammatory activity consisting Lactobacillus spp. Rhodopseudomonas palustris on macrophage RAW 264.7 cells.Methods: mixture centrifuged separate supernatant, i.e., extract, from cells. extract then evaluated effects cell viability LPS inflammation-induced RAW264.7 cells.Results: results showed that able decrease levels IFN-γ, IL-1β, TNF-α, IL-8, TGF-β1 cytokines/mRNAs, increase IL-10 mRNA.Conclusion: identified activity, it decreased increased cytokines/mRNAs.Keywords: multi-strain probiotics, cytokine/mRNA,